WHAT IS RESVERATROL?
Resveratrol (trans-3,5,4′-Trihydroxystilbene) belongs to a class of natural compounds called stilbenes. Resveratrol and other stilbenes are small molecules that are rapidly synthesized by plants in response to attacks by bacteria, fungi and predators. Stilbenes presently are the focus of numerous biomedical research studies. Compounds within this chemical class have displayed therapeutic potential through their capability to support a healthy inflammatory response in various tissues throughout the bodies of humans and animals.
HOW DOES RESVERATROL WORK?
Resveratrol is a proactive therapy that addresses inflammation before it occurs. Commonly used Non-steroidal anti-inflammatory drugs (NSAIDs), such as Bute or Banamine®, are the conventional treatment for chronic inflammatory conditions and generally are effective. But NSAIDs also produce unwanted side effects in many animals, including ulcers or kidney and liver dysfunction. Most modern NSAIDs are designed to specifically inhibit the pro-inflammatory cyclooxygenase enzymes (COX-2) as well as the gastro-protective form of the enzyme (COX-1). The COX-1 inhibitory activity of these NSAID products and associated gastrointestinal side effects, including ulcers, make them unsafe for long-term daily use. NSAIDs react to the body’s inflammatory response after it has begun and has affected tissues.
Conversely, resveratrol does not affect the body’s production of gastroprotective prostaglandins and does not have unwanted gastrointestinal side effects associated with NSAIDs. Rather than inhibiting inflammatory enzymes circulating in the body, resveratrol reduces gene expression of inflammatory mediators, such as COX-2, lipoxygenases, myeloperoxidases, nitrous oxide synthases and tumor necrosis factor alpha (TNFα). The result is a lower concentration of inflammatory mediators circulating in the body.
RESVERASYN®—STABLE, BIOAVAILABLE 99% RESVERATROL
Resveratrol must be in a purified and bioavailable formulation in order to be effective. Equithrive products contain a proprietary form of resveratrol called Resverasyn®. This is composed of 99% pure resveratrol that has been micronized and encapsulated. Micronization reduces the particle to a size where it is easily absorbed by the body, and encapsulation provides a coating that both protects the bioactive resveratrol from deterioration and increases the distribution of the molecule to affected tissues.
Resveratrol must be microencapsulated to guarantee maximum bioavailability and effectiveness. Without this process, resveratrol can be very unstable when exposed to light or oxygen and is rapidly metabolized and excreted before it can reach tissues for therapeutic effects.
Use of our microencapsulated resveratrol product, Resverasyn, ensures your horse will receive consistent therapeutic doses of bioavailable resveratrol. Equithrive products are easily administered in oral dosage forms rather than by injection. Equithrive products will not aggravate gastric ulcers, are safe for use with other medications and supplements, and contain no banned substances (FEI Compliant).
WHY IS EQUITHRIVE WITH RESVERASYN DIFFERENT?
Resverasyn is manufactured by first producing trans-resveratrol of minimum 99% purity level. Each production lot of our trans-resveratrol is analyzed via high performance liquid chromatography (HPLC) to ensure that the product meets our 99% purity specification before it is microencapsulated to become our proprietary product Resverasyn.