The supposed health benefits of red wine have been touted for centuries, and more recently, scientists are taking a closer look at one specific compound contained in red grape skin: resveratrol.
Numerous studies through the years have shown resveratrol to be a potentially effective treatment in humans for everything from slowing the cognitive decline in Alzheimers patients, to helping combat heart disease with its natural anti-inflammatory properties, and even fighting obesity. So it should come as no surprise that resveratrol based supplements are beginning to trickle into the animal health market. What's good for me should be good for my critters, right?
Well, before you pour that second glass and toast to the latest "medical miracle" there are some things to consider. Resveratrol research is still relatively new, and if you know anything about supplements, you're aware it does not require clinical evidence to land these products on shelves. Imprecise key factors like dosage levels, absorption rate and the quality of the resveratrol itself, have kept the forecast cloudy.
In 2016, researchers at Texas A&M studied the effectiveness of a resveratrol supplement for treating lameness in performance horses.
95% of the horses administered the resveratrol supplement Equithrive Joint showed noticeable improvement after four months of treatment (compared to 70% improvement from the placebo group).
“This type of study is especially rare in the equine supplement industry due to time and cost involved, and I was very pleased that Equithrive raised the standard for the industry," said Ashlee Watts, DVM, PhD, DACVS, who led the study.
So what else makes Equithrive's products different from other equine supplements?
Equithrive products contain a proprietary form of resveratrol called Resverasyn, which is 99% pure resveratrol that's been reduced in size to make it absorb easily, and encapsulated to protect the compound from deterioration before reaching tissues in the body.
See, while most people assume all resveratrol supplements are created equal, that is not the case. The commercial source for the vast majority of resveratrol products is a shrub named Japanese Knotweed (Polygonum cuspidatum) that is native to Asia and cultivated in China. Chinese manufacturing firms extract resveratrol from the rhizomes (underground stems) of the shrub and produce knotweed extracts that have resveratrol concentrations ranging anywhere from 20% to 98%. The corresponding percentage of impurities in these resveratrol products can range anywhere from 2% to 80%. There's really no way for the consumer to know. One of the impurities in knotweed-based resveratrol products is a compound called emodin, which has caused serious gastrointestinal distress in some users of knotweed-based resveratrol products.
The questionable purity and safety of resveratrol products derived from Japanese Knotweed raises cause for concern.
Equithrive, on the other hand, was developed by this dude, Dr. Patrick Lawless, in his company's lab on the campus of the University of Kentucky.
"I feel like to large degree, even in the animal pharmaceutical world, not enough attention is being paid to formulations that maximize the bioavailability of different compounds," Lawless explains. "There are many things you can do from a formulation perspective that will improve the bioavailability of a product. Resveratrol has extremely poor bioavailability, and if the manufacturer does not take steps to formulate it in a way that makes it more bioavailable for horses, you're wasting your time and money."
The benefits of Resverasyn go well beyond joint health. It is also serves as the key active ingredient in the Equithrive product Metabarol, which promotes healthy metabolic function.
A 2013 study at the Gluck Equine Research Center found that 45 days of continuous Metabarol administration reduced insulin levels by 25-30% in horses with Equine Metabolic Syndrome (EMS).
Resverasyn is not a "miracle-in-a-bottle" that will get your old retiree back in the Grand Prix; and it is not a cure for osteoarthritis. It is, however, clinically proven to be a thoroughly effective compliment to the daily diet without all the unwanted side effects, and you know exactly what you're getting with each dose.
Now that's news we can toast.