Proof

SCIENTIFICALLY TESTED AND PROVEN TO WORK

Equithrive was built on science. We have put our products through rigorous scientific testing at leading research institutions to demonstrate their safety and effectiveness. If you believe in products backed by scientific research, Equithrive is the company you should trust to provide products that will support the health and performance of your horse.


EQUITHRIVE® JOINT

Equithrive Joint has been evaluated in multiple university studies, with the following results:

  • Proven to support soundness in performance horses.1
  • Proven to support a healthy inflammatory response in performance horses.2
  • Proven to support healthy levels of free radicals in performance horses.3

You can learn more about the research on Equithrive Joint by clicking the links below to articles that have been published in peer-reviewed scientific publications.

1 “A randomized, controlled trial of the effects of resveratrol administration in performance  horses with lameness localized to the distal tarsal joints” from Journal of the American Veterinary Medical Association Link to Abstract

2 “Modulatory Effects of resveratrol Supplementation on Inflammatory Markers in Ageing and Lame Horses” from International Journal of Animal and Veterinary Advances

Link to Full Text

3 “Ameliorative Effects of resveratrol on Oxidative Stress Biomarkers in Horses” from Journal of Equine Veterinary Science Link to Abstract


METABAROL®

AQHA Funded Study Conducted at Gluck Equine Research Center (2013)

In 2012, the American Quarter Horse Association funded a research grant to investigate the metabolic effects of resveratrol administration in horses.

This research study was performed in 2013 by Dr. Amanda Adams at the Gluck Equine Research Center. In this study, 45 days of continuous Metabarol administration reduced insulin levels by 25-30% in horses enrolled in the study. Results independent of diet.

 


Download Dr. Adams’ abstract at EES

RESEARCH FROM PEER-REVIEWED SCIENTIFIC LITERATURE

There have been numerous peer-reviewed scientific studies published that demonstrate the metabolic effects of resveratrol administration. For a summary of this research, including literature citations, see below.

Resveratrol was the first compound identified to activate Sirtuin 1 (SIRT1)1, an enzyme that activates and deactivates select genes to improve metabolic function and enhance muscle performance. SIRT1 also is induced by exercise and caloric restriction. 2-5 Thus, resveratrol administration may offer some of the same health benefits of exercise and caloric restriction through its similar effects on SIRT1.

Resveratrol has been found to have the following therapeutic effects relating to metabolic function and muscle performance:

  • improves insulin sensitivity5-8

  • promotes mitochondrial biogenesis, the production of mitochondria in cells5,8

  • increases the efficiency of energy-producing metabolic reactions in mitochondria8,9

  • improves muscle recovery after exercise10

  • supports muscle tissue health with aging11,12

1  Expert Opinion on Therapeutic Patents. 2012 Apr;22(4):355-67.  A patent review of sirtuin activators: an update. Villalba et al.

2  Nature. 2006 Nov 16; 444 (7117):337-42. Resveratrol improves health and survival of mice on a high-calorie diet. Baur et al.

3  PLoS One. 2008 Jun 4;3 (6):2264. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. Barger et al.

4  Metabolism. 2008 Jul;57 (7):986-98. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator1alpha protein expressions in rat skeletal muscle. Suwa et al.

5  BMC Systems Biology. 2009 Mar 10;3:31. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. Smith et al.

6  Biomedical Pharmacotherapy. 2008 Nov;62(9):598-605. Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide-induced experimental diabetic rats. Palsamy and Subramanian.

7 Chemico-Biological Interactions. 2009 May 15;179(2-3):356-62. Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Palsamy and Subramanian.

8  Cell. 2006 Dec 15;127(6):1109-22. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Lagouge et al.

9  Cell Metabolism. 2012 May 2;15(5):675-90. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Price et al.

10  Journal of Applied Physiology. 2007 Sep;103 (3):1093-8. Role of myokines in exercise and metabolism. Pedersen et al.

11  American Journal of Physiology - Endocrinology and Metabolism. 2011 Nov;301(5):E853-63. Resveratrol ameliorates metabolic disorders and muscle wasting in streptozotocin-induced diabetic rats. Chen et al.

12  Federation of American Societies for Experimental Biology Journal. 2011 Oct;25(10):3646-60. Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat. Momken et al.